Journal
EUROPEAN JOURNAL OF PHARMACOLOGY
Volume 690, Issue 1-3, Pages 107-114Publisher
ELSEVIER
DOI: 10.1016/j.ejphar.2012.06.042
Keywords
Deprenyl; Neuropathy; Postsurgical pain; Nociception
Categories
Funding
- Conselho Nacional de Desenvolvimento Cientifico (CNPq)
- Financiadora de Estudos e Projetos (FINEP)
- Programa de Apoio aos Nucleos de Excelencia (PRONEX)
- Fundacao de Amparo a pesquisa do Estado do Rio Grande do Sul (FAPERGS)
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) (Brazil)
- CAPES
- CNPq
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In this study we assessed the involvement of monoamine oxidase B (MAO-B), a key enzyme implicated in monoamine metabolism, on postoperative (plantar incision) and neuropathic (partial sciatic nerve ligation) pain models in mice. Paw incision submitted mice showed a significant decrease in mechanical threshold compared with the sham-operated mice, characterizing the development of mechanical allodynia. The selective and irreversible MAO-B inhibitor selegiline, at a dose sufficient to selectively inhibit MAO-B activity (10 mg/kg), showed an anti-allodynic effect from 0.5 to 6 h after incision. Likewise, partial sciatic nerve ligation submitted mice also developed mechanical allodynia, which was reversed by selegiline (10 mg/kg) from 2 to 6 h after treatment. In addition, a significant increase on striatal MAO-B activity was observed in neuropathic mice compared with the sham-operated animals, which was reversed by selegiline treatment. Taken together, our results showed that MAO-B seems to exert a critical role in the development of postoperative and neuropathic pain. (C) 2012 Elsevier B.V. All rights reserved.
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