Journal
EUROPEAN JOURNAL OF PHARMACOLOGY
Volume 696, Issue 1-3, Pages 96-100Publisher
ELSEVIER
DOI: 10.1016/j.ejphar.2012.09.030
Keywords
Fluvoxamine; Forced swimming test; Paroxetine; SSRI (Selective serotonin reuptake inhibitor); Sigma(1) receptor
Categories
Ask authors/readers for more resources
We studied the involvement of the sigma(1) receptor in the antidepressant-like effects of the selective serotonin reuptake inhibitor (SSRI) fluvoxamine in DBA/2 mice using the forced swimming test. The effects of the selective sigma(1) receptor antagonist N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(dimethylamino) ethylamine (BD1047) at 1 mg/kg significantly antagonized the anti-immobility elicited by fluvoxamine (10 mg/kg). However, the anti-immobility effects elicited by another SSRI, paroxetine (5 m/kg), were not altered by BD1047. The selective sigma(1) receptor agonist 2S-(2 alpha,6 alpha,11R*)-1,2,3,4,5,6-hexahydro-6,11-dimethyl-3(2-propenyl)-2,6-methano-3-benzazocin-8-ol ((+)SKF-10047) elicited dose-dependent anti-immobility effects in DBA/2 mice. BD1047 significantly blocked the anti-immobility effects induced by (+)SKF-10047 at 10 mg/kg. These results suggested that the sigma(1) receptor was associated with fluvoxamine-induced antidepressant-like effects but not with paroxetine-induced antidepressant-like effects. (C) 2012 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available