Journal
EUROPEAN JOURNAL OF PHARMACOLOGY
Volume 685, Issue 1-3, Pages 198-204Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ejphar.2012.04.014
Keywords
Nicotinamide; Neutrophil-recruitment; Carrageenan; Pleurisy
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Funding
- Fundacao de Amparo a Pesquisa de Minas Gerais (FAPEMIG)
- Conselho Nacional de Pesquisa e Desenvolvimento (CNPq)/Brazil
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Several emerging lines of evidence support an anti-inflammatory role for nicotinamide and other vitamin B components. However, the mechanisms underlying their activity remain unclear. In the present study, we investigated the ability of nicotinamide to inhibit both neutrophil recruitment in IL-8-, LTB4- or carrageenan-induced pleurisy in mice and the rolling and adherence of neutrophils. Nicotinamide inhibited IL-8-, LTB4- and carrageenan-induced neutrophil migration, KC production and carrageenan-induced neutrophil rolling and adherence. We propose that the effects of nicotinamide in inhibiting neutrophil recruitment in carrageenan-induced pleurisy may be due to the ability of nicotinamide to inhibit the action of IL-8 and LTB4, decrease KC production, and inhibit early events that regulate leukocyte migration from blood vessels into tissue. (C) 2012 Elsevier B. V. All rights reserved.
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