Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 137, Issue 30, Pages 9507-9510Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.5b01123
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Funding
- Minerva Foundation
- HFSP Organization
- European Research Council
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The design and function of A synthetic chemical transducer that can generate an unnatural communication channel between two proteins is described. Specifically, we show how this transducer enables platelet-derived growth factor to trigger (in vitro) the catalytic activity of glutathione-s-transferase (GST), which is not Its natural enzyme partner. GST activity can be further controlled by adding specific oligonucleotides that switch the enzymatic reaction: on and off: We also demonstrate that a molecular machine, which can regulate the function of an enzyme, could be used to change the way a prodrug is activated in a programmable manner.
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