Journal
EUROPEAN JOURNAL OF PHARMACOLOGY
Volume 639, Issue 1-3, Pages 33-39Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ejphar.2009.12.042
Keywords
Metabotropic glutamate receptor 5; NMDA glutamate receptor; Schizophrenia; Prefrontal cortex; Cognitive enhancer
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Funding
- NIMH
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Group 5 metabotropic glutamate (mGlu(5)) receptors are abundant in forebrain and limbic regions and provide a novel pharmacological target for modulation of cognition. Here, we review recent advances in understanding the electrophysiology of these receptors which reveal a role for mGlu(5) receptors in the regulation of tonic and bursting modes of neuronal firing, maintenance of distinct forms of synaptic plasticity, and reversal of detrimental effects of NMDA receptor antagonism on cortical neuronal activity. Furthermore, recordings using recently developed positive allosteric modulators of the mGlu(5) receptor suggest that these agents have an electrophysiological profile comparable to the antipsychotic agent clozapine. These findings, in conjunction with behavioral evidence from preclinical studies of cognition, suggest a potential precognitive profile for the mGlu(5) receptor potentiators. (C) 2010 Elsevier B.V. All rights reserved.
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