Journal
EUROPEAN JOURNAL OF PHARMACOLOGY
Volume 648, Issue 1-3, Pages 6-14Publisher
ELSEVIER
DOI: 10.1016/j.ejphar.2010.08.045
Keywords
Phenothiazine; Antipsychotic; DNA double strand break (DSB); DNA repair; Apoptosis
Categories
Funding
- Council for Scientific and Industrial Research, India [09/096(0530)/2K8 EMR-I]
Ask authors/readers for more resources
The phenothiazine group of drugs has long been known as antipsychotic drugs and previously it was extensively used for the treatment of anxiety. Several pieces of evidence have shown that they interfere with a variety of cellular processes and in vitro can interact with biomolecules like DNA, proteins etc. Recent reports have also revealed some new properties like antimicrobial, antiprionic, anticancerous activities of certain members of the phenothiazine group. Appropriate clinical application of phenothiazines can be developed in the future after gaining a comprehensive knowledge about their function. Information relating to the toxic and beneficial effects of these drugs has been discussed in this review. (C) 2010 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
