Journal
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
Volume 88, Issue 1, Pages 207-215Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ejpb.2014.04.012
Keywords
Cellulose nanocrystals; Drug selective electrode; Isothermal titration calorimetry; In vitro drug release; Procaine hydrochloride; Imipramine hydrochloride
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Funding
- CelluForce
- AboraNano
- CFI
- NSERC
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Native cellulose nanocrystal (CNC), oxidized CNC (CNC-OX) and chitosan oligosaccharide grafted CNC (CNC-CSOS) were evaluated as potential drug delivery carriers for two model drug compounds, procaine hydrochloride (PrHy) and imipramine hydrochloride (IMI). The loading of PrHy and IMI was performed at pH 8 and 7, respectively. IMI displayed higher binding to CNC derivatives than PrHy. Drug selective membranes were prepared for each model drug and a drug selective electrode system was used to measure the drug concentration in the filtrate and release medium. Isothermal Titration Calorimetry (ITC) was used to elucidate the types of interactions between model drugs and CNC and its derivatives. The complexation between model drugs and CNC derivatives was confirmed by zeta potential and transmittance measurements. The binding and release of these drugs correlated with the nature and types of interactions that exist between the CNC and drug molecules. (C) 2014 Elsevier B.V. All rights reserved.
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