Journal
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
Volume 86, Issue 2, Pages 292-300Publisher
ELSEVIER
DOI: 10.1016/j.ejpb.2013.10.011
Keywords
Burn; Skin; Atomic force microscopy; Technetium-99m; In vivo cicatrization
Categories
Funding
- CAPES/Brazil fellowship
- INCT-IF/CNPq
- CNPq/Brasilia/Brazil
- CNPq Brazil Mexico [490166/2011]
- Rede Nanocosmeticos CNPq (Brazil)
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The use of drug-loaded nanoparticles and microparticles has been increasing, especially for cosmetic and drug delivery purposes. In this work, a new microparticle formulation was developed for use in the healing process of skin burns in a composition of Aloe vera/vitamin E/chitosan. In order to observe the morphological properties, Raman and atomic force microscopy evaluation were performed. The biodistribution studies were analyzed by using a nuclear methodology, labeling the microparticles with Technetium-99m and in vivo test was procedure to analyzed the cicatrization process. The results of AFM analysis show the formation and the adherence property of the microparticles. Raman analyses show the distribution of each component in the microparticle. The nuclear method used shows that the biodistribution of the microparticles remained in the skin. The in vivo cicatrization test showed that the poloxamer gel containing the microparticles make a better cicatrization in relation to the other formulations tested. (c) 2013 Elsevier B.V. All rights reserved.
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