Journal
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
Volume 84, Issue 1, Pages 91-98Publisher
ELSEVIER
DOI: 10.1016/j.ejpb.2012.11.019
Keywords
Mesoporous silica; Nanoparticle; pH-responsive; Composite microsphere; Crosslinking density; Drug delivery
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Funding
- National Science Foundation of China [20874015, 51273047]
- Shanghai Rising-Star Program [10QH1400200]
- Innovation Program of Shanghai Municipal Education Commission [09ZZ01]
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pH-responsive composite microspheres, consisting of a core of Fe3O4 nanoparticle, a sandwiched layer of mesoporous silica and a shell of crosslinked poly (methacrylic acid) (PMAA), were successfully synthesized via distillation precipitation polymerization. The pKa of the composite microsphere increased with the increase in the crosslinking density. Doxorubicin hydrochloride (DOX) was applied as a model drug, and the behavior of drug storage/release was investigated. The cumulative release of DOX-loaded composite microsphere in vitro showed that the drug release rate was much faster below its pKa than that of above its pKa. Because pH of most tumor tissues was lower than that of normal tissues, the pH-responsive composite microspheres are promising drug delivery system especially for cancer therapy. (C) 2012 Elsevier B.V. All rights reserved.
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