Journal
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
Volume 78, Issue 3, Pages 336-345Publisher
ELSEVIER
DOI: 10.1016/j.ejpb.2010.12.031
Keywords
Layer-by-layer self-assembly; Poly(L-glutamic acid); Chitosan; 5-Fluorouracil; Drug delivery systems
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Funding
- National Natural Science Foundation of China [51003055, 50973060]
- Science and Technology Commission of Shanghai Municipality [08JC1410300]
- Shanghai Leading Academic Discipline Project [s30107]
- Shanghai Municipal Education Commission [11YZ06]
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Hollow polyelectrolyte microcapsules based on poly(L-glutamic acid) (PLGA) and chitosan (CS) with opposite charges were fabricated by layer-by-layer (LbL) assembly technique using melamine formaldehyde (MF) microparticles as sacrificial templates. The LbL assembly of polyelectrolytes and the resultant PLGA/CS microcapsules were characterized. A hydrophilic anticancer drug, 5-fluorouracil (5-FU), was chosen to investigate the loading and release properties of the microcapsules. The PLGA/CS microcapsules show high loading capacity of 5-FU under conditions of high drug concentration and salt adding. The high loading can be ascribed to spontaneous deposition of 5-FU induced by hydrogen bonding between 5-FU and PLGA/CS microcapsules. The PLGA/CS microcapsules show sustained release behavior. The release rate of 5-FU drastically slows down after loading in PLGA/CS microcapsules. The 5-FU release from PLGA/CS microcapsules can be best described using Ritger-Peppas or Baker-Londale models, indicating the diffusion mechanism of 5-FU release from the PLGA/CS microcapsules. In vitro cytotoxicity evaluation by the MTT assay shows good cell viability over the entire concentration range of PLGA/CS microcapsules. Therefore, the novel PLGA/CS microcapsules are expected to find application in drug delivery systems because of the properties of biodegradability, high loading, sustained release and cell compatibility. (C) 2010 Elsevier B.V. All rights reserved.
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