Journal
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
Volume 73, Issue 3, Pages 357-360Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ejpb.2009.07.005
Keywords
Host-guest interaction; Supramolecular gels; Gelator; 5-Fluorouracil
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Funding
- National Key fundamental Research Plan of China [2006CB933301]
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Supramolecular organogels were formed by the self-assembly of gelator 1,3:2,4-di-O-benzylidene-D-sorbitol (DBS) in 1,2-propylene glycol. 5-Fluorouracil (5-Fu) was entrapped in the organogels as guest molecules. Field-emission scanning electron microscopic measurements of the organogels indicate that the diameters of the fibrillar aggregates formed by DBS self-assembly were in the range of 20-70 nm. The host-guest interactions between 5-Fu and supramolecular gel matrix were investigated by using temperature-dependent differential UV spectroscopy and differential scanning calorimetry. The red shifts of the absorption band of 5-Fu in the organogels are indicative of the interaction between 5-Fu and DBS. The red shifts were enhanced upon decreasing the temperature. Calculation of optimized geometries revealed the formation of hydrogen bonds between 5-Fu and DBS aggregates. The analysis of differential scanning calorimetric data for the organogels with and without 5-Fu further showed that the self-assembly of DBS was interfered by the 5-Fu in the organogels, resulting in a decrease in the dissociating temperature of DBS aggregates. (C) 2009 Elsevier B.V. All rights reserved.
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