Journal
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
Volume 72, Issue 3, Pages 595-599Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ejpb.2009.02.009
Keywords
Electroosmosis; Electroosmotic flow; Iontophoresis; Buccal mucosa; Skin
Categories
Funding
- Polish Ministry of Science and Higher Education
- European Union
Ask authors/readers for more resources
The objective of this study was to investigate and to better understand the properties of buccal mucosa as a semipermeable membrane and a portal for drug administration by iontophoretic and electroosmotic means. In vitro experiments showed that buccal mucosa at the pH of about 7.4 behaved as a cation-exchange membrane and non-linear resistor. It had lower resistance and was more permeable for water than a skin. The electroosmotic volume flow through mucosa depended on current density, mucosa resistance and electrolyte concentration. Sodium dodecyl sulfate (in concentration range 0.001-0.005 mol L-1) and urea (in concentration range 0.42-1.67 mol L-1) did not promote a water transfer through buccal mucosa, however, both Substances enhanced flow through the skin. (C)2009 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available