Journal
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
Volume 69, Issue 3, Pages 1040-1045Publisher
ELSEVIER
DOI: 10.1016/j.ejpb.2008.02.009
Keywords
microneedle; calcein; permeation; gel; delivery systems
Categories
Funding
- Chungnam National University
- Ministry of Education, Science & Technology (MoST), Republic of Korea [Kaist_KI_2008_27] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [과C6A1808, R11-2001-089-07002-0] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Despite the advantages of drug delivery through the skin, such as easy accessibility, convenience, prolonged therapy, avoidance of the liver first-pass metabolism and a large surface area, transdermal drug delivery is only used with a small subset of drugs because most compounds cannot cross the skin at therapeutically useful rates. Recently, a new concept was introduced known as microneedles and these could be pierced to effectively deliver drugs using micron-sized needles in a minimally invasive and painless manner. In this study, biocompatible polycarbonate (PC) microneedle arrays with various depths (200 and 500 mu m) and densities (45, 99 and 154 ca/cm(2)) were fabricated using a micro-mechanical process. The skin permeability of a hydrophilic molecule, calcein (622.5D), was examined according to the delivery systems of microneedle, drug loading, depth of the PC microneedle, and density of the PC microneedle. The skin permeability of calcein was the highest when the calcein gel was applied to the skin with the 500 mu m-depth PC microneedle, simultaneously. in addition, the skin permeability of calcein was the highest when 0.1 g of calcein gel was coupled to the 500 gm-depth PC microneedle (154 ea/cm(2)) as well as longer microneedles and larger density of microneedles. Taken together, this study suggests that a biocompatible PC microneedle might be a suitable tool for transdermal drug delivery system of hydrophilic molecules with the possible applications to macromolecules such as proteins and peptides. (C) 2008 Elsevier B.V. All rights reserved.
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