Journal
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
Volume 68, Issue 1, Pages 34-45Publisher
ELSEVIER
DOI: 10.1016/j.ejpb.2007.02.025
Keywords
thermosensitive hydrogels; in situ gelation; drug delivery; tissue engineering; lower critical solution temperature
Categories
Funding
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R01AR048756] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DENTAL &CRANIOFACIAL RESEARCH [R01DE015164] Funding Source: NIH RePORTER
- NIAMS NIH HHS [R01 AR048756-07, R01 AR 48756, R01 AR048756] Funding Source: Medline
- NIDCR NIH HHS [R01 DE015164, R01 DE 15164, R01 DE015164-05] Funding Source: Medline
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Environmentally responsive hydrogels have the ability to turn from solution to gel when a specific stimulus is applied. Thermoresponsive hydrogels utilize temperature change as the trigger that determines their gelling behavior without any additional external factor. These hydrogels have been interesting for biomedical uses as they can swell in situ under physiological conditions and provide the advantage of convenient administration. The scope of this paper is to review the aqueous polymer solutions that exhibit transition to gel upon temperature change. Typically, aqueous solutions of hydrogels used in biomedical applications are liquid at ambient temperature and gel at physiological temperature. The review focuses mainly on hydrogels based on natural polymers, N-isopropylacrylamide polymers, poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide) polymers as well as poly(ethylene glycol)-biodegradable polyester copolymers. (c) 2007 Elsevier B.V. All rights reserved.
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