Journal
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
Volume 70, Issue 1, Pages 171-178Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ejpb.2008.04.017
Keywords
kappa-carrageenan; basic butylated methacrylate copolymer; interpolyelectrolyte complexes; ibuprofen; matrix systems; controlled release
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Funding
- National Research Council of Argentina (CONICET) [PIP 5467]
- Agencia Nacional de Promocion Cientifica y Tecnologica (ANPCyT) [PICT 06-14237]
- University of Buenos Aires [X325, X045]
- ANPCyT
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The formation of a novel interpolyelectrolyte complex (IPEC) between basic butylated methacrylate copolymer and kappa-carrageenan was investigated and the product formed was characterized. Turbidity measurements and elemental analyses pointed to a 1:1 interaction of the repeating units. These results and FT-IR confirmed IPEC formation. Electronic microscopy images, particle size determination by image analysis and NZ (77 K) adsorption measurements were consistent with a porous material. This IPEC formed presented very good flowability and compactibility. Two maxima were observed in the swelling behaviour as a function of pH. The performance of the IPEC as a matrix for controlled release of drugs was evaluated, using ibuprofen as a model drug. Release profiles were properly represented by a mathematical model, which indicates that the system releases ibuprofen in a zero-order manner. These profiles could be controlled by conveniently modifying the proportion of the IPEC in the tablets. (c) 2008 Elsevier B.V. All rights reserved.
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