Journal
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
Volume 53, Issue -, Pages 10-16Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ejps.2013.11.016
Keywords
Nano-fiber patch; Intraocular pressure; Mucoadhesive strength; Draize test
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In the present work polymeric nano-fiber patches was developed for the effective treatment of glaucoma using timolol maleate and dorzolamide hydrochloride as model drugs. The nano-fibers were prepared by electrospinning technique and were characterized on the basis of fiber diameter, morphology, entrapment efficiency, mucoadhesive strength, and drug release behavior, etc. Final formulations were inserted in the cul-de-sac of glaucoma induced rabbits and the efficacy of the formulation was evaluated. The results clearly indicated the potential of the developed formulation for occur drug delivery. There was a significant fall in the intraocular pressure compared to commercial eye drops. (C) 2013 Elsevier B.V. All rights reserved.
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