Journal
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
Volume 60, Issue -, Pages 40-48Publisher
ELSEVIER
DOI: 10.1016/j.ejps.2014.04.020
Keywords
Thermo-sensitive; Organogel; Phase inversion; Sustained release; In situ forming system
Categories
Funding
- NIH/NCI [HHSN261 201000051C]
- Open Project Program of State Key Laboratory of Long-acting Targeting Drug Delivery System, Yantai, China [264000]
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Novel biodegradable in situ forming organogel, obtained via the self-assembly of long chain fatty acid in pharmaceutical oil, was prepared and characterized. Different from traditional organogels, the use of organic solvent was avoided in this gel system, in consideration of its tissue irritation. Four kinds of fatty acids were employed as organogelators, which could successfully gel with injectable soybean oil. The gelation procedure was thermo-reversible. Phase transition temperature and time were depended on carbon chain length and concentration of gelators. Optimized formulations containing drug were then injected subcutaneously in rats for pharmacokinetic study. Results showed the steady drug release for one week with the well-controlled burst, which fitted well with the drug release mechanism of both drug diffusion and frame erosion. In vivo imaging of the organogel with fluorescence in live animals suggested that the organogel matrix was gradually absorbed and completely up-taken in nine days. Histopathological analysis of the surrounding tissues was carried out and revealed an overall good biocompatibility property of the implants over drug release period. This research demonstrates that this thermo-sensitive in situ forming organogel system represents a potentially promising platform for sustained drug delivery. (C) 2014 Elsevier B.V. All rights reserved.
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