Journal
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
Volume 38, Issue 4, Pages 405-413Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ejps.2009.09.010
Keywords
Nanoparticles; Bioadhesion; Poly(anhydride); Cyclodextrin; Paclitaxel; Ussing chambers; Intestinal permeability
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The aim of this work was to study the effect of the combination between 2-hydroxypropyl-beta-cyclodextrin (HPCD) and bioadhesive nanoparticles on the encapsulation and intestinal permeability of paclitaxel (PTX). In this context, a solid inclusion Complex between PTX and HPCD was prepared by an evaporation method. Then, the complex was incorporated in poly(anhydride) nanoparticles by a solvent displacement method. The resulting nanoparticles, PTX-HPCD NP, displayed a size of about 300 nm and a drug loading of about 170 mu g/mg (500-fold higher than in the absence of HPCD). The effect of these nanoparticles oil the permeability of intestinal epithelium was investigated using the Ussing chamber technique. The apparent permeability (P-app) of PTX was found to be 12-fold higher when formulated as PTX-HPCD NP than when formulated as Taxol(R) (control). Furthermore, when interaction between nanoparticles and the mucosa was avoided, the permeability of PTX significantly decreased. In summary. the association between PTX-HPCD and poly(anhydride) nanoparticles would induce a positive effect over the intestinal permeability of paclitaxel, being the bioadhesion a mandatory condition in this phenomena. (C) 2009 Elsevier B.V. All rights reserved.
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