Journal
EUROPEAN JOURNAL OF PEDIATRIC SURGERY
Volume 24, Issue 3, Pages 219-226Publisher
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0034-1378150
Keywords
regenerative medicine; stem cell; amniotic fluid; mesenchymal stem cells; NEC
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Funding
- National Institute for Health Research [RP_2014-04-046] Funding Source: researchfish
- Department of Health [RP_2014-04-046] Funding Source: Medline
- National Institutes of Health Research (NIHR) [RP_2014-04-046] Funding Source: National Institutes of Health Research (NIHR)
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Regenerative medicine aims to replace, repair, or restore normal function of cells, tissues, and organs that are damaged by disease and holds a promising potential for the treatment of congenital anomalies. Herein, we present an overview of the different stem cell populations and discuss the potentials and most recent updates in stem cell therapy relevant to pediatric surgeons. In particular, we focus on stem cell applications in intestinal regeneration for necrotizing enterocolitis, liver regeneration in biliary atresia and human hepatocyte transplantation for liver failure, and pulmonary regeneration of hypoplastic lungs due to prematurity or congenital diaphragmatic hernia.
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