Journal
EUROPEAN JOURNAL OF PAIN
Volume 19, Issue 8, Pages 1071-1074Publisher
WILEY-BLACKWELL
DOI: 10.1002/ejp.639
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Funding
- Taipei Veterans General Hospital [V100D-001, V100D-001-1, V100D-001-2, VN103-05]
- Ministry of Science and Technology [NSC 100-2314-B-010-006-MY3, NSC 100-2629-B-010-001, NSC 101-2629-B-010-001, NSC 102-2629-B-010-001]
- Ministry of Education for National Yang-Ming University
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BackgroundPrimary dysmenorrhoea (PDM) is inexorably common. PDM women suffer from cramping pain in the lower abdomen that starts with menstruation and lasts for 24-72h. Up to 90% of adolescent girls and more than 50% of menstruating women worldwide report suffering from it. Ten to 20% of PDM women describe their suffering as severe and distressing. However, nothing is known regarding the association of PDM with possible brain anomalies or abnormalities. MethodsHigh-resolution T1-weighted anatomical brain magnetic resonance images (MRI) were acquired for each subject and inspected for incidental findings (normal variants and abnormalities) as a routine procedure in our PDM-related multimodal neuroimaging studies. Altogether, 330 right-handed young women [otherwise healthy PDMs=163; non-PDM healthy controls (HCs)=167] were enrolled during the period of 2006-2014. Binomial proportion test was performed for between-group comparisons. ResultsPDMs demonstrated significantly higher prevalence of overall incidental brain MRI findings (PDMs: n=18, 11.0%; HCs: n=6, 3.6%; p=0.005) that should be ascribed to a preponderance of normal variants (PDMs: n=16, 9.8%; HCs: n=3, 1.8%; p=0.001), especially cavum septum pellucidum. No significant between-group difference of abnormal findings was found (PDMs: n=2, 1.2%; HCs: n=3, 1.8%; p=0.336). ConclusionsWe report here that otherwise healthy PDMs are associated with high prevalence of normal variants but not brain abnormalities. Our observations invite further epidemiological and neuroscientific studies.
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