Synthesis of Chromone-Containing Allylmorpholines through a Morita-Baylis-Hillman-Type Reaction

The first example of an unusual addition of chromone-substituted acrylic acid to enamines is described. The process shows high versatility concerning both enamines and chromones. The reaction is catalyzed by tertiary amines and is highly likely of Morita-Baylis-Hillman-type. The described compounds show combined moderate inhibitory action on BChE and antagonism towards NMDA receptors which makes them a perspective group for the development of anti-Alzheimer drugs.