Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2018, Issue 31, Pages 4345-4348Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201800680
Keywords
Synthetic methods; Cleavage reactions; Detrifluoroacetylation; Retro-Claisen reaction; Succinimides; 1; 4-Diketones
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Funding
- Tianjin Vocational College of Bioengineering [201610055]
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Currently, a great deal of research efforts are focused on C-C bond activation for development of novel synthetic methodology. In this paper, a detrifluoroacetylation of trifluoromethyl--diketones is described, which allows for the synthesis of succinimides and 1,4-diketones through cascade Michael addition/retro-Claisen reaction and nucleophilic substitution/retro-Claisen reaction. The readily available trifluoromethyl--diketones, wide substrate scope, and mild conditions make this method very practical.
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