Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2014, Issue 26, Pages 5806-5815Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201402386
Keywords
Synthetic methods; Nitrogen heterocycles; Amines Amides; Aluminium
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A simple, convenient and general method, exhibiting good functional group tolerance, is described for the synthesis of N- and N,N-disubstituted amidines by the reaction of primary carboxamides with amines mediated by trimethylaluminium (AlMe3). Subsequent reaction of the indole systems with primary carboxamides in the presence of AlMe3 gives exclusively the C-3 substituted imine product.
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