Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2014, Issue 19, Pages 3991-3995Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201402516
Keywords
Synthetic methods; Photoaffinity labeling; C-H borylation; Azides; Diazido building blocks
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Funding
- Platform for Drug Discovery, Informatics, and Structural Life Science, Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan
- Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan
- Grants-in-Aid for Scientific Research [26102717] Funding Source: KAKEN
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Short synthetic routes to diazido building blocks with different connectable groups were established on the basis of the sequential iridium-catalyzed C-H borylation and copper-catalyzed azidation of 1,3-disubstituted benzenes, followed by diverse azido-friendly functional-group transformations. These building blocks facilitate the rapid development of effective diazido photoaffinity labeling probes that are useful for the identification of unknown target biomolecules of bioactive compounds.
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