Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2014, Issue 20, Pages 4244-4247Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201402332
Keywords
Synthetic methods; Cleavage reactions; Amidation; Carboxylic acids; Amines; Copper
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Funding
- National Natural Science Foundation of China (NSFC) [U1162109, 21273066, 21273067]
- Program for New Century Excellent Talents in Universities [NCET-10-0371]
- Fundamental Research Funds for Central Universities (Hunan University)
- Canon Foundation
- Hunan University (HNU)
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A copper-catalyzed system for the amidation of carboxylic acids with tert-amines through C-N bond cleavage was developed. This protocol is practical and represents a simple way to produce functionalized amides from basic starting materials in moderate to good yields. A plausible mechanism is proposed for the reaction.
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