Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2014, Issue 25, Pages 5469-5475Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201402395
Keywords
Domino reactions; Nitrogen heterocycles; Palladium; Regioselectivity; Chemoselectivity
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Funding
- National Institute of Pharmaceutical Education & Research (NIPER) S.A.S. Nagar
- Council of Scientific and Industrial Research (CSIR), New Delhi
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A general method has been developed for the synthesis of fused nitrogen heterocycles by using a domino N-benzylation/C-H arylation reaction sequence. The details and yields of the domino process were compared with those of the two-step literature protocol. Fused azaindoles, which are otherwise difficult to obtain, were synthesized by using this process. The unprecedented catalytic role of PPh3 in this N-benzylation is described.
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