Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2014, Issue 17, Pages 3519-3530Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201402149
Keywords
Peptides; Cysteine; Selenocysteine; Oxidation; Disulfide formation; Protecting groups
Categories
Funding
- Direccion General de Investigacion Ciencia y Tecnica (DGICYT) [CTQ2009-07758, SAF2011-27642, CTQ2012-30930]
- Generalitat de Catalunya [2009SGR249]
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Disulfide bonds play an important role in both proteins and peptides. They cause conformational constraints and increase the stability of such molecules. In nature, disulfide bonds are very common in animal and plant peptide toxins. These disulfide-rich peptides typically bind very selectively with high affinities to their targets. Disulfide-rich peptides are of great importance as potential therapeutics. Robust, convenient, and efficient methods are needed in order to prepare disulfide-rich peptides to facilitate the drug discovery process. This microreview explores new cysteine protecting groups that replace obsolete protecting groups, reduce racemization, or facilitate regioselective disulfide formation, new disulfide formation strategies to assist in the synthesis of complex disulfide-rich peptides, and the use of selenocysteine to direct disulfide formation.
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