Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2014, Issue 32, Pages 7232-7238Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201402977
Keywords
Total synthesis; Natural products; Peptides; Amino acids; Antitumor agents; Sulfonamides
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Funding
- National Natural Science Foundation of China (NSFC) [1272052]
- National Basic Research Program of China [2011CB512007, 2012CB723501]
- Hebei Province Natural Science Fundation [B2014208138]
- Foundation of the Education Department of Hebei Province [ZH2012025]
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This paper describes an efficient procedure for the synthesis of micromide, a natural product that shows anti-solid-tumor activity. Our strategy involved the synthesis of N-nosyl-protected amino acids and their N-methylation with iodomethane. The hindered oligopeptides containing N-methyl amino acids were synthesized in excellent yields and high purities.
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