Related references
Note: Only part of the references are listed.Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001-2011)
Jiang Wang et al.
CHEMICAL REVIEWS (2014)
Chemistry of Bridged Lactams and Related Heterocycles
Michal Szostak et al.
CHEMICAL REVIEWS (2013)
Synthesis and Characterization of β-Trifluoromethyl-Substituted Pyrrolidines
Vladimir S. Yarmolchuk et al.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2013)
Tetrazole-Substituted Five, Six, and Seven-Membered Cyclic Amines Bearing Perfluoroalkyl Groups - Efficient Synthesis by Azido-Ugi Reaction
Olga I. Shmatova et al.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2013)
On the polarity of partially fluorinated methyl groups
Quentin A. Huchet et al.
JOURNAL OF FLUORINE CHEMISTRY (2013)
Synthesis of trans-2-(Trifluoromethyl)cyclopropanes via Suzuki Reactions with an N-Methyliminodiacetic Acid Boronate
Matthew A. J. Duncton et al.
ORGANIC LETTERS (2013)
Synthesis of 2-and 3-trifluoromethylmorpholines: useful building blocks for drug discovery
Andriy V. Shcherbatiuk et al.
TETRAHEDRON (2013)
Metabolically Stable tert-Butyl Replacement
David Barnes-Seeman et al.
ACS MEDICINAL CHEMISTRY LETTERS (2013)
A facile synthetic route to 2-trifluoromethyl-substituted polyfunctionalized chromenes and chromones
Lele Wen et al.
JOURNAL OF FLUORINE CHEMISTRY (2012)
Simple synthesis of 1,1-bis(trifluoromethyl)cyclopropanes
Viacheslav A. Petrov et al.
JOURNAL OF FLUORINE CHEMISTRY (2012)
Synthesis of 1-Alkyl-2-(trifluoromethyl)azetidines and Their Regiospecific Ring Opening toward Diverse α-(Trifluoromethyl)Amines via Intermediate Azetidinium Salts
Sara Kenis et al.
JOURNAL OF ORGANIC CHEMISTRY (2012)
Synthesis of Trifluoromethyl-Substituted Cyclopropanes via Sequential Kharasch-Dehalogenation Reactions
Julie Risse et al.
ORGANIC LETTERS (2012)
Incorporation of cis- and trans-4,5-Difluoromethanoprolines into Polypeptides
Vladimir S. Kubyshkin et al.
ORGANIC LETTERS (2012)
Enantioselective Cobalt-Catalyzed Preparation of Trifluoromethyl-Substituted Cyclopropanes
Bill Morandi et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2011)
Discovery of 4-aminomethylphenylacetic acids as γ-secretase modulators via a scaffold design approach
Zhili Xin et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2011)
(5S)-5-(Trifluoromethyl)pyrrolidin-2-one as a Promising Building Block for Fluoroorganic Chemistry
Andrii V. Bezdudny et al.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2011)
β-(Trifluoromethyl)vinyl Sulfonium Salts: Preparation and Reactions with Active Methylene and Methenyl Compounds
Hao Lin et al.
JOURNAL OF ORGANIC CHEMISTRY (2011)
Iron-Catalyzed Preparation of Trifluoromethyl Substituted Vinyl- and Alkynylcyclopropanes
Bill Morandi et al.
ORGANIC LETTERS (2011)
Trifluoromethyl-substituted cyclopropanes
Oleksandr O. Grygorenko et al.
TETRAHEDRON (2011)
The reaction of cyclic imines with the Ruppert-Prakash reagent. Facile approach to α-trifluoromethylated nornicotine, anabazine, and homoanabazine
Nikolay E. Shevchenko et al.
TETRAHEDRON (2011)
Iron-Catalyzed Cyclopropanation with Trifluoroethylamine Hydrochloride and Olefins in Aqueous Media: In Situ Generation of Trifluoromethyl Diazomethane
Bill Morandi et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2010)
Rhodium-Catalyzed Cyclopropenation of Alkynes: Synthesis of Trifluoromethyl-Substituted Cyclopropenes
Bill Morandi et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2010)
Synthesis, SAR and intramolecular hydrogen bonding pattern of 1,3,5-trisubstituted 4,5-dihydropyrazoles as potent cannabinoid CB1 receptor antagonists
Jos H. M. Lange et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2010)
Synthesis of 2-Azabicyclo[4.1.0]heptanes through Stereoselective Cyclopropanation Reactions
Irene Suarez del Villar et al.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2010)
Rigid Analogues of the α2-Adrenergic Blocker Atipamezole: Small Changes, Big Consequences
Bernard Vacher et al.
JOURNAL OF MEDICINAL CHEMISTRY (2010)
Enantioselective Hydroformylation of N-Vinyl Carboxamides, Allyl Carbamates, and Allyl Ethers Using Chiral Diazaphospholane Ligands
Richard I. McDonald et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)
Dibutyl 2-(trifluoromethyl)cyclopropylboronate as a useful (trifluoromethyl)cyclopropyl donor: application to antagonists of TRPV1
Matthew A. J. Duncton et al.
TETRAHEDRON LETTERS (2010)
Dopamine D3 receptor antagonists: The quest for a potentially selective PET ligand. Part two: Lead optimization
Fabrizio Micheli et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)
Fluorine in medicinal chemistry: a century of progress and a 60-year retrospective of selected highlights
Robert Filler et al.
FUTURE MEDICINAL CHEMISTRY (2009)
Synthesis of trifluoromethyl-substituted proline analogues as F-19 NMR labels for peptides in the polyproline II conformation
Pavel K. Mykhailiuk et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2008)
Fluorine in medicinal chemistry
Sophie Purser et al.
CHEMICAL SOCIETY REVIEWS (2008)
Fluoroalkyl substituted (Z)-dehydro alpha-amino ester as a building block for the fluorine-containing cyclopropyl alpha-amino esters and dihydrooxazole
Wen Wan et al.
JOURNAL OF FLUORINE CHEMISTRY (2008)
The many roles for fluorine in medicinal chemistry
William K. Hagmann
JOURNAL OF MEDICINAL CHEMISTRY (2008)
Fluorination in medicinal chemistry: Methods, strategies, and recent developments
Kenneth L. Kirk
ORGANIC PROCESS RESEARCH & DEVELOPMENT (2008)
ONE-POT CONVERSION OF LACTAM CARBAMATES TO CYCLIC ENECARBAMATES: PREPARATION OF 1-TERT-BUTOXYCARBONYL-2,3-DIHYDROPYRROLE
Jurong Yu et al.
ORGANIC SYNTHESES (2008)
Enantioselective synthesis of trifluoromethyl-substituted cyclopropanes
Justin R. Denton et al.
ORGANIC LETTERS (2007)
Trifluoromethylated cyclopropanes and epoxides from CuI-mediated transformations of α-trifluoromethyl-diazophosphonate
Igor D. Titanyuk et al.
JOURNAL OF FLUORINE CHEMISTRY (2007)
Virtual exploration of the chemical universe up to 11 atoms of C, N, O, F: Assembly of 26.4 million structures (110.9 million stereoisomers) and analysis for new ring systems, stereochemistry, physicochemical properties, compound classes, and drug discovery
Tobias Fink et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2007)
Preorganization in biological systems: Are conformational constraints worth the energy?
Stephen F. Martin
PURE AND APPLIED CHEMISTRY (2007)
Stereochemical diversity-oriented conformational restriction strategy.: Development of potent histamine H3 and/or H4 receptor antagonists with an imidazolylcyclopropane structure
Mizuki Watanabe et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
Cyclic sulfamide γ-secretase inhibitors
T Sparey et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2005)
Diazo compounds and phenyliodonium ylides in inter- and intramolecular cyclopropanations catalyzed by Dirhodium(II).: Synthesis and chiral resolution by GC versus HPLC
A Ghanem et al.
MONATSHEFTE FUR CHEMIE (2005)
Exploring ramachandran and Chi space: Conformationally constrained amino acids and peptides in the design of bioactive polypeptide ligands
SM Cowell et al.
CURRENT MEDICINAL CHEMISTRY (2004)
Stereospecific synthesis of trifluoromethyl-substituted polyfunctionalized cyclopropanes
Y Wang et al.
TETRAHEDRON LETTERS (2004)
Rh(II)-Catalyzed asymmetric carbene transfer with ethyl 3,3,3-trifluoro-2-diazopropionate
P Müller et al.
TETRAHEDRON (2004)
Fluorine in medicinal chemistry
HJ Böhm et al.
CHEMBIOCHEM (2004)
A convenient stereoselective synthesis of trifluoromethyl-substituted polyfunctionalized cyclopropane: synthesis of (+/-)-trans-trifluoronorcoronamic acid
BA Jiang et al.
CHEMICAL COMMUNICATIONS (2003)
Synthesis, structure and reactions of the most twisted amide
AJ Kirby et al.
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2 (2001)
Diastereoselectivity controlled by electrostatic repulsion between the negative charge on a trifluoromethyl group and that on aromatic rings
T Katagiri et al.
CHEMICAL COMMUNICATIONS (2001)
Syntheses of optically active trifluoronorcoronamic acids
T Katagiri et al.
ORGANIC LETTERS (2000)
Selective reactions of 1,1-cycloalkanedicarboxylic acids with SF4.: A route to 1,1-bis(trifluoromethyl)cycloalkanes, 1-fluoroformyl-1-(trifluoromethyl)cycloalkanes and 1-(trifluoromethyl)-1-cycloalkanecarboxylic acids
W Dmowski et al.
JOURNAL OF FLUORINE CHEMISTRY (2000)