4.5 Article

Synthesis of Trifluoromethyl-Substituted 3-Azabicyclo[n.1.0]alkanes: Advanced Building Blocks for Drug Discovery

Journal

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2014, Issue 17, Pages 3592-3598

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201402158

Keywords

Fluorine; Synthetic methods; Trifluoromethyldiazomethane; Nitrogen heterocycles; Drug discovery

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Five CF3-substituted 3-azabicyclo[n.1.0]alkanes were synthesized by CuCl-mediated trifluoromethylcyclopropanation reaction of the corresponding cyclic enamides with CF3CHN2.

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