Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2014, Issue 19, Pages 3976-3980Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201402262
Keywords
Natural products; Terpenoids; Norsesquiterpenes; Endophytic fungi; Cytotoxic activity; Configuration determination
Categories
Funding
- The Thailand Research Fund
- Center of Excellence on Environmental Health and Toxicology, Science & Technology Postgraduate Education and Research Development Office (PERDO), Ministry of Education
- Office of the Higher Education Commission, Ministry of Education through Higher Education Research Promotion and National Research University Project [WCU-016-FW-57]
- ASEAN Foundation
- Thailand International Development Cooperation Agency (TICA)
Ask authors/readers for more resources
The new tricyclic and spirobicyclic norsesquiterpenes 1 and 2 and the new nor-chamigrane endoperoxide 3, together with the known sesquiterpenes steperoxide A (4), merulin B (5), and merulin C (6), were isolated from the endophytic fungus Pseudolagarobasidium acaciicola. The structures and absolute configurations of 1-3 were determined by analysis of spectroscopic data, as well as by single-crystal X-ray analysis. Compound 1 has a previously unobserved 6/5/5 fused tricyclic ring system, in which the five-membered (middle) ring is, as revealed by X-ray analysis, perpendicular to a six-membered ring. Compound 2 possesses a hitherto unknown 5/6 fused spirobicyclic ring system. The cytotoxic activities of the isolated compounds 1-6 were evaluated.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available