Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2014, Issue 16, Pages 3491-3495Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201402019
Keywords
Alkaloids; Asymmetric catalysis; Hydroxylation; beta-Dicarbonyl compounds; Organocatalysis
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Funding
- National Natural Science Foundation of China [21176041]
- State Key Laboratory of Fine Chemicals
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A new framework derived from the commercially available diterpenoid alkaloid lappaconitine was evaluated as a Bronsted base catalyst for the enantioselective alpha-hydroxylation of beta-dicarbonyl compounds by using 30% hydrogen peroxide as a green and highly practical source of oxygen. This protocol allows convenient access to the corresponding alpha-hydroxy-beta-oxo esters, alpha-hydroxy-beta-oxo amides and (-)-kjellmanianone with up to 98% yield and 92% ee.
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