Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2014, Issue 36, Pages 8055-8063Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201403233
Keywords
Synthetic methods; C-H activation; Oxidation; Amination; Nitrogen heterocycles; Iron
Categories
Funding
- Department of Science and Technology (DST), New Delhi [SB/S1/OC-72/2013]
- Department of Science and Technology (DST), Nano Mission, New Delhi [SR/NM/NS-1034/2012(G)]
- Council of Scientific and Industrial Research (CSIR), New Delhi
Ask authors/readers for more resources
The efficient and selective iron-catalyzed C-H activation of 2-benzhydrylpyridine derivatives was employed for the preparation of pyrido[1,2-a]indoles through an intramolecular C-H amination reaction. In the presence of molecular oxygen as the sole oxidant, the same 2-benzhydrylpyridines were also used for the synthesis of the corresponding tertiary alcohols. In these approaches, the iron catalyst was used to selectively activate the C(sp(2))-H bond of 2-benzhydrylpyridine, in the case of the intramolecular ring-closing C-H amination reaction in which the pyridine nitrogen atom was a directing group as well as a nucleophile, and the C(sp(3))-H bond of the same compound, in the case of the oxidation reaction to give the corresponding triaryl carbinol.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available