Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2014, Issue 10, Pages 2092-2098Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201301613
Keywords
Natural products; Total synthesis; Lactones; Coupling reactions; Metathesis
Categories
Funding
- National Basic Research Program of China [2012CB822101]
- National Innovative Drug Fundation [2012ZX09502001]
- National Natural Science Foundation of China (NSFC) (NSF of China) [21072217, 21232002]
Ask authors/readers for more resources
Divergent syntheses of two 14-membered resorcylic acid lactones (RALs), cochliomycin B (6) and zeaenol (22), have been accomplished. The key feature in our strategy was the facile construction of three contiguous stereogenic centers in the title molecules by using natural L-arabinose as the chiral template. The key reactions included Takai olefination, Suzuki cross coupling, transesterification, and a late-stage ring-closing metathesis (RCM).
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available