Rapid Access to Multiple Classes of Peptidomimetics from Common γ-AApeptide Building Blocks

Herein we report a highly efficient new method for preparing -AApeptides capable of theoretically containing any functionality; the method uses a few common N-alloc -AApeptide building blocks. More importantly, using the same approach, new classes of peptidomimetics bearing novel backbone scaffolds can also be readily generated. Our results not only demonstrate the versatility of this new synthetic method, but also highlight the possibility that the resulting novel peptidomimetics may find discrete biomedical/biomaterial applications in the future.