Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2013, Issue 34, Pages 7697-7704Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201301230
Keywords
Organocatalysis; Amino acids; Water chemistry; Green chemistry; Michael addition
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Funding
- Austrian Science Fund (FWF) through an Erwin-Schroedinger Fellowship [J3292]
- China Scholarship Council/Delft University of Technology Joint Program
- Austrian Science Fund (FWF) [J3292] Funding Source: Austrian Science Fund (FWF)
- Austrian Science Fund (FWF) [J 3292] Funding Source: researchfish
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The use of water as a nucleophile for Michael additions is still a challenge in organic chemistry. In this report we describe the use of amino acids as catalysts for the Michael addition of water to ,-unsaturated ketones. All 20 proteinogenic amino acids were screened and L-lysine was identified as the best candidate. To obtain a better insight and to determine the minimum requirements of the catalyst, several structurally related compounds were tested. The reaction was characterized in terms of conditions and equilibrium.
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