Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2013, Issue 17, Pages 3470-3476Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201300057
Keywords
Supramolecular chemistry; Self-assembly; Molecular recognition; Polymers; Multivalency
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Funding
- European Research Council (ERC) [204554, 310275]
- Center for Translational Molecular Medicine (CTMM) [03O-201]
- European Research Council (ERC) [310275, 204554] Funding Source: European Research Council (ERC)
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Supramolecular synthesis, the bottom-up construction of higher-order structures from monomeric building blocks, represents a flexible approach for the generation of multivalent materials. Here, monovalent building blocks decorated with a single bioactive ligand were synthesized. In water, these supramolecular elements self-assemble into columnar polymers that display multiple ligands. The supramolecular effect on the binding affinity was evaluated by using an enzyme-linked lectin assay, and the self-assembled architecture exhibited a stronger inhibitory power than that of the monovalent bioactive ligand. This so-called self-assembling multivalency enables the rapid and flexible generation of multivalent polymers from monovalent building blocks.
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