Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2013, Issue 20, Pages 4345-4350Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201300334
Keywords
Cross-coupling; Heterogeneous catalysis; Palladium; Biaryls; Liquid crystals
Categories
Funding
- National Natural Science Foundation of China [21076034, 20923006]
- Ministry of Education
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An aerobic, ligand-free Suzuki reaction catalyzed by Pd/C in aqueous media has been developed. This method is a very simple, efficient and mild protocol for the cross-coupling of aryl bromides with arylboronic acids, and the reactions proceeded smoothly in excellent yields within short reaction times. Control experiments demonstrated that the Pd/C-catalyzed Suzuki reaction was much quicker when performed in air or oxygen than in nitrogen. Furthermore, this protocol could be used for the synthesis of fluorinated liquid-crystalline compounds. The Pd/C catalyst could be recovered and recycled efficiently at least ten times without significant loss of catalytic activity.
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