Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2014, Issue 6, Pages 1333-1337Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201301543
Keywords
Medicinal chemistry; Glycomimetics; Bioisosteres; Carbohydrates; Phosphorus heterocycles
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Funding
- Idenix Pharmaceuticals, Montpellier, France (IDENIX)
- Agence Nationale de la Recherche et de la Technologie (ANRT)
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The first synthesis of new cyclic phosphonates (phostones), analogues of pentafuranoses containing a phosphorus atom in place of the anomeric carbon in the deoxyribose and deoxyxylose series, is described. Two methods, of respectively six and seven steps, were developed in parallel, and each gave the racemic phosphonosugars in good yields. Compounds analogous to the alpha and beta anomers were isolated and fully characterized by NMR spectroscopy.
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