Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2012, Issue 15, Pages 2875-2887Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201101821
Keywords
DNA; DNA recognition; Nucleobases; Nucleotides; Oligonucleotides; Carbohydrates; Triple helix
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Funding
- Grants-in-Aid for Scientific Research [22136006] Funding Source: KAKEN
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Triplex formation with double-stranded DNA (dsDNA) by oligonucleotides has potential for applications in attractive technologies such as gene therapy and genetic diagnosis. However, triplex-forming oligonucleotides (TFOs) can only recognize homopurine strands in homopurine-homopyrimidine regions in dsDNA, either through Hoogsteen or through reverse-Hoogsteen hydrogen bonds. A straightforward and powerful approach to overcoming this sequence limitation is the development of artificial nucleic acids capable of recognizing specific pyrimidine-purine interruptions (i.e., a CG or TA base pair) in triplex formation. This review describes artificial nucleic acids, especially those containing non-natural nucleobases, developed to recognize CG or TA base pairs in dsDNA targets.
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