Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2013, Issue 3, Pages 456-459Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201201335
Keywords
Organocatalysis; Asymmetric synthesis; Heterocycles; Michael addition; Enantioselectivity
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Funding
- National Natural Science Foundation of China (NSFC) [21102117]
- Education Department of Sichuan Province [10ZA026]
- Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province [11CSPC-1-1]
- Bureau of Science & Technology and Intellectual Property Nanchong City [12A0036]
- China West Normal University [10B005]
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Enantioselective Michael addition of oxazolones to in situ generated vinylogous imine intermediates is reported. A series of optically active 3-alkylindole derivatives with adjacent quaternary and tertiary stereocenters was obtained. The resulting adducts can readily be converted into syn-configured alpha,beta-disubstituted tryptophan derivatives without compromising the stereoselectivities.
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