Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2012, Issue 19, Pages 3607-3616Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201200308
Keywords
Total synthesis; Synthetic methods; Natural products; Palladium; Lactones; Arenediazonium salts
Categories
Funding
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (Capes)
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
- FAPESP
- CNPq
Ask authors/readers for more resources
Herein, we describe the total syntheses of three bioactive pyrones isolated from Polygala sabulosa (i.e., 1, 4, and 7) and eight isolated from Piper methysticum (i.e., 810, 13, 15, and 1820) using the HeckMatsuda arylation as the key strategy. The evaluation of this methodology by employing different arenediazonium tetrafluoroborates revealed that the Heck arylation was more efficient when the olefin undergoing arylation possessed the vinyl-2-pyrone structural unit instead of the vinyl dihydro-2-pyrone moiety. The HeckMatsuda arylation of many of the examined olefins proceeded in a practical manner with total regio- and stereocontrol.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available