Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2012, Issue 31, Pages 6260-6270Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201200938
Keywords
Carbohydrates; Epimerization; Synthesis design; Phosphorylation
Categories
Funding
- University of Hamburg
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A convenient approach to the chemical synthesis of L-altrose (1) and its 6-deoxy derivative 2 has been developed by starting from D-galactose (9) and D-fucose (10), respectively. The 5-epimerization by a Mitsunobu inversion of the open-chain D-hexoses was the key step for these routes. Furthermore, the conversion of 2 into peracetylated TDP-6-deoxy-a-L-altrose (3a) was achieved by the cycloSal approach. However, the final deacetylation led to an unexpected side-reaction resulting in the previously unknown 6-deoxy-a-L-altropyranose 1,3-cyclophosphate (4).
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