Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2012, Issue 30, Pages 5913-5917Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201201086
Keywords
Chemoselectivity; Protecting groups; Alkynes; Alcohols; Benzyl ether
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Funding
- National Research Foundation of Korea [NRF 3\201100000000663]
- Brain Korea 21program (BK21)
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We have discovered the highly chemoselective benzylation of propargylic hydroxy groups in the presence of other hydroxy groups under very usual conditions involving benzyl bromide and sodium hydroxide in DMF at room temperature. This methodology has a high synthetic utility for the selective protection of hydroxy groups at the propargylic position among various other hydroxy groups in complex molecules.
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