Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2013, Issue 3, Pages 443-447Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201201405
Keywords
C-F bond activation; Palladium; Cross-coupling; Boron; Fluorine
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Funding
- Ministry of Education, Culture, Sports, Science, and Technology (MEXT) of Japan [21245028]
- [23105546]
- Grants-in-Aid for Scientific Research [25708018, 21245028] Funding Source: KAKEN
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A new strategy for C-C bond formation with organoboronates through C-F activation of fluorinated alkenes and arenes was developed. In this Pd-catalyzed Suzuki-Miyauratype cross-coupling reaction, neither a base for enhancing the reactivity of the organoboron reagents nor a Lewis acid for promoting C-F bond activation was required. A fluoropalladium intermediate played an essential role in this reaction. In addition, a Ni(NHC) catalyst was efficient for C-C coupling through C-F bond activation of fluoroarenes.
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