Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2013, Issue 1, Pages 35-39Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201201258
Keywords
Amines; Nitrogen heterocycles; Silver; Cyclization; Reaction mechanisms
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Funding
- Ministerio de Ciencia e Innovacion (MICINN) [SAF2009-07271, SAF2012-33304, CTQ2009-10478]
- Comunidad de Madrid (Spain) [BIPEDD-2: S2010-BMD2457]
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We report herein the silver-catalyzed cycloisomerization of readily available N-(prop-2-yn-1-yl) pyridine-2-amines as a new and practical method for the synthesis of differently substituted 3-methylimidazo[1,2-a] pyridines. The isomerization reactions proceeded under mild reactions conditions to give good yields and excellent regioselectivity. A DFT-based mechanistic analysis is also reported.
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