Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2012, Issue 21, Pages 3946-3954Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201200327
Keywords
Amino acids; Peptides; Fluorinated substituents; Conformation analysis; Helical structures
Categories
Funding
- American Chemical Society [46219-AC4]
- National Science Foundation (NSF) [CHE0957544]
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [0957544] Funding Source: National Science Foundation
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The design and synthesis of pentafluorosulfanyl-containing heptad amino acid sequence was described. The three-dimensional conformation of the peptide was investigated by using CYANA (combined assignment and dynamics algorithm for NMR applications) and the integrated autoassignment. This study shows that the one of the diastereomers assumed a very tight coiled conformation in [D6]DMSO where both pentafluorosulfanyl groups assumed a synclinal relationship. The propensity of the protected heptapeptide to form such a tight coil and of the pentafluorosulfanyl groups to align so uniformly is suggestive of the utility of pentafluorosulfanylated amino acids in promoting conformational control.
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