Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2011, Issue 30, Pages 6078-6084Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201100791
Keywords
Organocatalysis; Synthetic methods; Michael addition; Enantioselectivity; Heterocycles
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Funding
- National Natural Science Foundation of China (NSFC) [20772030, 21072056]
- Fundamental Research Funds for the Central Universities
- Scientific Research Foundation for Returned Overseas Chinese Scholars
- Ministry for State Education
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A highly enantioselective Michael addition of 3-aryloxindole to phenyl vinyl sulfone catalyzed by a quinine-derived bifunctional amine-thiourea-bearing sulfonamide as multiple hydrogen-bonding donor catalyst has been investigated. The corresponding adducts, which contain a chiral quaternary carbon center at the 3-position of the oxindole, were obtained in moderate-to-good yields (52-86%) with high-to-excellent enantioselectivities (83-98% ee).
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