4.5 Review

Transition-Metal-Mediated Routes to 3,3-Disubstituted Oxindoles through Anilide Cyclisation

Journal

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2011, Issue 34, Pages 6821-6841

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201100836

Keywords

Oxindoles; Synthesis; Transition metals; Heck reaction; Enolate aryl-ations; C-H activation; Natural product synthesis

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This review describes transition-metal-catalysed and -mediated processes for the preparation of oxindoles from anilides through C(3)C(3a) bond formation. Traditional methods, such as the Heck reaction, and recent developments, including direct ArH coupling processes, are presented, as are applications in natural product synthesis.

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