4.5 Article

An Easy Access to Carbazolones and 2,3-Disubstituted Indoles

Journal

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2011, Issue 12, Pages 2360-2365

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201001357

Keywords

Nitrogen heterocycles; Cyclization; Iron

Funding

  1. National Science Council of the Republic of China
  2. National Taiwan Normal University [99T3030-2, 99D]

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Synthesis of carbazol-4-ones, 3,4-dihydrocyclopental-indol-1-one, and indole derivatives by a Fe/AcOH-mediated intramolecular reductive N-heteroannulation of 3-hydroxy-2-(2-nitrophenyl)enones is demonstrated. The same protocol has been extended to access indolocarbazolone and indoloquinolone derivatives.

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